St. Clare Catholic Church serves the people of the southern part of Madison County, Kentucky. 

In addition, the church also provides religious direction, and the staff serve as chaplain to the Newman Club of Berea College.  Many of the catholic students of the college attend St. Clare Catholic Church, and the church provides on campus services for the students.

St. Clare Catholic Chuch is also joined with St. Paul Catholic Church in McKee, Jackson County, Kentucky, and Our Lady of Mount Vernon in Mount Vernon, Rockcastle County, Kentucky.

Each parish community is independent, with its own local staff and specific mission for their counties, although they share the services of the priest for pastoral direction and for the sacramental life of each parish.